Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets.

ABSTRACT: Cyclotron-produced astatine-211 (²¹¹At) shows tremendous promise in targeted alpha therapy (TAT) applications due to its attractive half-life and its 100% α-emission from nearly simultaneous branched alpha decay. Astatine-211 is produced by alpha beam bombardment of naturally monoisotopic bismuth metal (²⁰⁹Bi) via the (α, 2n) reaction. In order to isolate the small mass of ²¹¹At (specific activity = 76 GBq·µg^-1) from several grams of acid-dissolved Bi metal, a manual milliliter-scale solvent extraction process using diisopropyl ether (DIPE) is routinely performed at the University of Washington. As this process is complex and time consuming, we have developed a fluidic workstation that can perform the method autonomously. The workstation employs

SUBMITTER: O'Hara MJ 

PROVIDER: S-EPMC6937302 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature