Enhanced oligomerization of full-length RAGE by synergy of the interaction of its domains.

ABSTRACT: The pattern recognition receptor RAGE (receptor for advanced glycation end-products) transmits proinflammatory signals in several inflammation-related pathological states, including vascular diseases, cancer, neurodegeneration and diabetes. Its oligomerization is believed to be important in signal transduction, but RAGE oligomeric structures and stoichiometries remain unclear. Different oligomerization modes have been proposed in studies involving different truncated versions of the extracellular parts of RAGE. Here, we provide basic characterization of the oligomerization patterns of full-length RAGE (including the transmembrane (TM) and cytosolic regions) and compare the results with oligomerization modes of its four truncated fragments. For this purpose, we used native mass spectrometry

SUBMITTER: Moysa A 

PROVIDER: S-EPMC6937306 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature