Immunosuppressive Tumor Microenvironment Status and Histological Grading of Endometrial Carcinoma.

ABSTRACT: The recent successes of new cancer immunotherapy approaches have led to investigate their relevance in the context of the Endometrial Carcinoma (EC). These therapies, that take the tumor-induced immunosuppressive microenvironment into account, target the tumor immune escape, in particular the inhibitory receptors involved in the regulation of the effector T cells' activity (immune checkpoints). The aim of this study was to identify, in ECs, differences in intergrades immune status that could contribute to the differences in tumor aggressiveness, and could also be used as theranostic tools. The immune status of tumors was assessed by quantitative real-time PCR. We analyzed the expression of specific genes associated to specific leukocytes subpopulations and the expression of reporting genes

SUBMITTER: Antomarchi J 

PROVIDER: S-EPMC6937359 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature