Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment.

ABSTRACT: Metabolic reprogramming is a newly emerged hallmark of cancer attaining a recent consideration as an essential factor for the progression and endurance of cancer cells. A prime event of this altered metabolism is increased glucose uptake and discharge of lactate into the cells surrounding constructing a favorable tumor niche. Several oncogenic factors help in promoting this consequence including, pyruvate kinase M2 (PKM2) a rate-limiting enzyme of glycolysis in tumor metabolism via exhibiting its low pyruvate kinase activity and nuclear moon-lightening functions to increase the synthesis of lactate and macromolecules for tumor proliferation. Not only its role in cancer cells but also its role in the tumor microenvironment cells has to be understood for developing the small molecules agains

SUBMITTER: Rihan M 

PROVIDER: S-EPMC6937361 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature