Overlapping genetic effects between suicidal ideation and neurocognitive functioning.

ABSTRACT:

Background

Suicide is the second leading cause of death among adolescents and young adults. Several studies have indicated significant genetic influences on suicide-related phenotypes and mounting evidence from neurobiological research has linked deficits in neurocognitive abilities to suicide phenotypes. The goal of the present study was to estimate the heritability of suicidal ideation (SI) in a large sample of adolescents and determine if SI is genetically correlated with neurocognitive functioning.

Methods

Genome-wide data (N = 3564 unrelated individuals of European Ancestry) were drawn from the Philadelphia Neurodevelopment Cohort. Adolescents completed a psychiatric assessment, as well as a computerized neurocognitive battery to assess performance across four domains:

SUBMITTER: Brick LA 

PROVIDER: S-EPMC6937431 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature