Ontology highlight
ABSTRACT:
SUBMITTER: Leung L
PROVIDER: S-EPMC6937593 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20190523 12
Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer therapy, and thus the search for therapeutic agents against LOX has been widely sought. We report herein the medicinal chemistry discovery of a series of LOX inhibitors bearing an aminomethylenethiophene (AMT) scaffold. High-throughput screening provided the initial hits. St ...[more]