CoQ₁₀ enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium.

ABSTRACT:

Background

Expression of mitochondrial proteins is reduced within hibernating myocardium (HM). It is unclear whether dietary supplementation with CoQ₁₀ can increase expression of mitochondrial electron transport chain (ETC) and antioxidant proteins within this tissue. In a swine model of HM, we tested whether dietary administration of CoQ₁₀ for four weeks enhances the expression of ETC and antioxidant proteins within the mitochondria via increased PGC1α signaling.

Methods

12 swine were instrumented with a fixed constrictor around the LAD artery to induce gradual stenosis. At three months, transthoracic ECHO was performed to confirm the presence of a wall motion abnormality in the anterior wall. Animals were then randomly assigned to receive daily dietar

SUBMITTER: Hocum Stone L 

PROVIDER: S-EPMC6937679 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature