High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis.

ABSTRACT:

Background

The mammalian intestine is a complex biological system that exhibits functional plasticity in its response to diverse stimuli to maintain homeostasis. To improve our understanding of this plasticity, we performed a high-level data integration of 14 whole-genome transcriptomics datasets from samples of intestinal mouse mucosa. We used the tool Centrality based Pathway Analysis (CePa), along with information from the Reactome database.

Results

The results show an integrated response of the mouse intestinal mucosa to challenges with agents introduced orally that were expected to perturb homeostasis. We observed that a common set of pathways respond to different stimuli, of which the most reactive was the Regulation of Complement Cascade pathway. Altered expression of

SUBMITTER: Benis N 

PROVIDER: S-EPMC6937694 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature