Proximal femoral head transcriptome reveals novel candidate genes related to epiphysiolysis in broiler chickens.

ABSTRACT:

Background

The proximal femoral head separation (FHS) or epiphysiolysis is a prevalent disorder affecting the chicken femur epiphysis, being considered a risk factor to infection which can cause bacterial chondronecrosis with osteomyelitis in broilers. To identify the genetic mechanisms involved in epiphysiolysis, differentially expressed (DE) genes in the femur of normal and FHS-affected broilers were identified using RNA-Seq technology. Femoral growth plate (GP) samples from 35-day-old commercial male broilers were collected from 4 healthy and 4 FHS-affected broilers. Sequencing was performed using an Illumina paired-end protocol. Differentially expressed genes were obtained using the edgeR package based on the False Discovery Rate (FDR < 0.05).

Results

Approximately 16 mi

SUBMITTER: de Oliveira Peixoto J 

PROVIDER: S-EPMC6937697 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature