Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity.

ABSTRACT:

Background

Gut microbiota has been increasingly acknowledged to shape significantly human health, contributing to various autoimmune diseases, both intestinal and non-intestinal, including multiple sclerosis (MS). Gut microbiota studies in patients with relapsing remitting MS strongly suggested its possible role in immunoregulation; however, the profile and potential of gut microbiota involvement in patients with primary progressive MS (PPMS) patients has received much less attention due to the rarity of this disease form. We compared the composition and structure of faecal bacterial assemblage using Illumina MiSeq sequencing of V3-V4 hypervariable region of 16S rRNA genes amplicons in patients with primary progressive MS and in the healthy controls.

Results

Over all samples

SUBMITTER: Kozhieva M 

PROVIDER: S-EPMC6937728 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature