Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma.

ABSTRACT:

Background

Increasing studies have suggested that aberrant expression of microRNAs might play essential roles in the progression of cancers. In this study, we sought to construct a high-specific and superior microRNAs signature to improve the survival prediction of colon adenocarcinoma (COAD) patients.

Methods

The genome-wide miRNAs, mRNA and lncRNA expression profiles and corresponding clinical information of COAD were collected from the TCGA database. Differential expression analysis, Kaplan-Meier curve and time-dependent ROC curve were calculated and performed using R software and GraphPad Prism7. Univariate and multivariate Cox analysis was performed to evaluate the prognostic ability of signature. Functional enrichment analysis was analyzed using STRING database.

Res

SUBMITTER: Ma R 

PROVIDER: S-EPMC6937800 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature