Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis-a binational multicenter cohort study.

ABSTRACT:

Background

The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock.

Methods

Retrospective binational multicenter cohort study of all ICUs contributing to the Australian and New Zealand Paediatric Intensive Care Registry. We included patients < 16 years admitted to ICU with sepsis and septic shock between 2002 and 2016. Sepsis-specific risk-adjusted models to establish ECMO benefit thresholds with mortality as the primary outcome were performed. Models were based on clinical variables available early after admission to ICU. Multivariate analyses were performed to identify predictors of survival in children treated with ECMO.

R

SUBMITTER: Schlapbach LJ 

PROVIDER: S-EPMC6937937 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature