Downregulated SPINK4 is associated with poor survival in colorectal cancer.

ABSTRACT:

Background

SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown.

Methods

We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO) datasets (GSE24551, GSE39582, GSE32323) and The Cancer Genome Atlas (TCGA) to compare the expression level of SPINK4 between CRC tissues and normal colorectal tissues and to evaluate its value in predicting the survival of CRC patients. At the protein level, these results were further confirmed by data mining in the Human Protein Atlas and by immunohistochemical staining of samples from 81 CRC cases in our own center.

Results

SPINK4 expression was downre

SUBMITTER: Wang X 

PROVIDER: S-EPMC6938003 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature