Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis.

ABSTRACT: Although chronic bacterial infections and inflammation are associated with progressive lung disease in patients with cystic fibrosis (CF), much less is known regarding the contributions of respiratory viral infections to this process. Clinical studies suggest that antiviral host defenses may be compromised in individuals with CF, and CF airway epithelia exhibit impaired antiviral responses in vitro. Here, we used the CF pig model to test the hypothesis that the antiviral activity of respiratory secretions is reduced in CF. We developed an in vitro assay to measure the innate antiviral activity present in airway surface liquid (ASL) from CF and non-CF pigs. We found that tracheal and nasal ASL from newborn non-CF pigs exhibited dose-dependent inhibitory activity against severa

SUBMITTER: Berkebile AR 

PROVIDER: S-EPMC6938132 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature