Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity.

ABSTRACT: Innate lymphoid cells (ILCs) are tissue-resident lymphoid cells that reside mostly at barrier surfaces and participate in the initial response against pathogens. They are classified into different types based on effector programs that are based on cytokine production and transcription factor expression. They all derive from the common lymphoid precursor, but the molecular mechanisms regulating ILC subset development is not well understood. Experiments using Id2 knockout mice have previously shown that E protein activity inhibition is an absolute requirement for the development of all ILC subsets. In this study, we use a genetic approach to demonstrate that small increases in E protein activity during ILC development selectively inhibit type 2 ILC development. Type 1 ILCs are mostly unpertu

SUBMITTER: Berrett H 

PROVIDER: S-EPMC6938226 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature