Neurocognitive changes after awake surgery in glioma patients: a retrospective cohort study.

ABSTRACT: PURPOSE:Deficits in neurocognitive functioning (NCF) frequently occur in glioma patients. Both treatment and the tumor itself contribute to these deficits. In order to minimize the harmful effects of surgery, an increasing number of patients undergo awake craniotomy. To investigate whether we can indeed preserve cognitive functioning after state-of-the art awake surgery and to identify factors determining postoperative NCF, we performed a retrospective cohort study. METHODS:In diffuse glioma (WHO grade 2-4) patients undergoing awake craniotomy, we studied neurocognitive functioning both pre-operatively and 3-6 months postoperatively. Evaluation covered five neurocognitive domains. We performed analysis of data on group and individual level and evaluated the value of patient-, tumor- and tr

SUBMITTER: van Kessel E 

PROVIDER: S-EPMC6938472 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature