The elevated systemic cytokine levels in HIV patients are not associated with an elevated pulmonary cytokine environment.

ABSTRACT:

Background

HIV-positive patients on anti-retroviral therapy (ART) are at higher risk of developing many non-AIDS related chronic diseases, including chronic obstructive pulmonary disease (COPD), compared to HIV-negative individuals. While the mechanisms are not clear, a persistent pro-inflammatory state appears to be a key contributing factor. The aims of this study were to investigate whether HIV-positive patients without COPD present evidence of potentially predisposing abnormal pulmonary cytokine/chemokine environment and to explore the relationship between pulmonary and systemic cytokine levels.

Methods

This study included 39 HIV-seropositive and 34 HIV-seronegative subjects without COPD. All were subjected to outpatient bronchoscopy with bronchoalveolar lavage fluid (BA

SUBMITTER: Fernandez-Botran R 

PROVIDER: S-EPMC6938540 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature