Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.

ABSTRACT:

Introduction

Some models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset.

Methods

We created dementia risk scores in 268 familial frontotemporal lobar degeneration family members by entering covariate-adjusted standardized estimates of brain atrophy into a logistic regression to classify asymptomatic versus demented participants. The score's predictive value was tested in a separate group who were followed up longitudinally (stable vs. converted to dementia) using Cox proportional regression

SUBMITTER: Staffaroni AM 

PROVIDER: S-EPMC6938544 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature