Internalizing and externalizing psychopathology in middle age: genetic and environmental architecture and stability of symptoms over 15 to 20 years.

ABSTRACT:

Background

Internalizing and externalizing psychopathology factors explain much of the covariance among psychiatric conditions, especially at the level of genetic risk. However, few studies have examined internalizing and externalizing factors in middle-aged samples, especially their ability to predict later symptoms across midlife. The goals of the current study were (i) to quantify the genetic and environmental influences on internalizing and externalizing psychopathology in individuals in their early 40s, and (ii) examine the extent to which these genetic and environmental influences predict self-reported measures of internalizing and externalizing symptoms 15-20 years later.

Method

1484 male twins completed diagnostic interviews of psychopathology at mean age 41 and self

SUBMITTER: Gustavson DE 

PROVIDER: S-EPMC6938573 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature