Systematic prediction of functionally linked genes in bacterial and archaeal genomes.

ABSTRACT: Functionally linked genes in bacterial and archaeal genomes are often organized into operons. However, the composition and architecture of operons are highly variable and frequently differ even among closely related genomes. Therefore, to efficiently extract reliable functional predictions for uncharacterized genes from comparative analyses of the rapidly growing genomic databases, dedicated computational approaches are required. We developed a protocol to systematically and automatically identify genes that are likely to be functionally associated with a 'bait' gene or locus by using relevance metrics. Given a set of bait loci and a genomic database defined by the user, this protocol compares the genomic neighborhoods of the baits to identify genes that are likely to be functionally linke

SUBMITTER: Shmakov SA 

PROVIDER: S-EPMC6938587 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature