Newborn and childhood differential DNA methylation and liver fat in school-age children.

ABSTRACT:

Background

Non-alcoholic fatty liver disease is the most common chronic liver disease in children in western countries. Adverse early-life exposures are associated with higher liver fat percentages in children. Differential DNA methylation may underlie these associations. We aimed to identify differential DNA methylation in newborns and children associated with liver fat accumulation in childhood. We also examined whether DNA methylation at 22 cytosine-phosphate-guanine sites (CpGs) associated with adult non-alcoholic fatty liver disease is associated with liver fat in children. Within a population-based prospective cohort study, we analyzed epigenome-wide DNA methylation data of 785 newborns and 344 10-year-old children in relation to liver fat fraction at 10 years. DNA methylatio

SUBMITTER: Geurtsen ML 

PROVIDER: S-EPMC6938624 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature