An epigenome-wide association study of sex-specific chronological ageing.

ABSTRACT:

Background

Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown to be associated with both age and sex. Here, we investigate age-by-sex differences in blood-based DNA methylation in an unrelated cohort of 2586 individuals between the ages of 18 and 87 years, with replication in a further 4450 individuals between the ages of 18 and 93 years.

Methods

Linear regression models were applied, with stringent genome-wide significance thresholds (p < 3.6 × 10^-8) used in both the discovery and replication data. A second, highly conservative mixed linear model method that better controls the false-pos

SUBMITTER: McCartney DL 

PROVIDER: S-EPMC6938636 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature