Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives.

ABSTRACT: Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. A significant amount of substantiation from epidemiological, clinical and laboratory research highlights the importance of diet and nutrition in cancer chemoprevention. Enterolactone (EL) is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Here in we review the reported anti-cancer properties of EL at preclinical as well as clinical l

SUBMITTER: Mali AV 

PROVIDER: S-EPMC6938675 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature