Homeostasis and transitional activation of regulatory T cells require c-Myc.

ABSTRACT: Regulatory T cell (T_reg) activation and expansion occur during neonatal life and inflammation to establish immunosuppression, yet the mechanisms governing these events are incompletely understood. We report that the transcriptional regulator c-Myc (Myc) controls immune homeostasis through regulation of T_reg accumulation and functional activation. Myc activity is enriched in T_regs generated during neonatal life and responding to inflammation. Myc-deficient T_regs show defects in accumulation and ability to transition to an activated state. Consequently, loss of Myc in T_regs results in an early-onset autoimmune disorder accompanied by uncontrolled effector CD4⁺ and CD8⁺ T cell responses. Mechanistically, Myc regulate

SUBMITTER: Saravia J 

PROVIDER: S-EPMC6938709 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature