Polymorphism in ASCL1 target gene DDC is associated with clinical outcomes of small cell lung cancer patients.

ABSTRACT:

Background

Achaete-scute homolog 1 (ASCL1) is a basic helix-loop-helix transcription factor and is essential in the differentiation of neuroendocrine cells and neural tissues. ASCL1 is frequently overexpressed in small cell lung cancer (SCLC) and plays a crucial role in the pathogenesis of SCLC.

Methods

This study was conducted to identify the association between single nucleotide polymorphisms (SNPs) in ASCL1 target genes and clinical outcomes of patients with SCLC after chemotherapy. A total of 261 patients diagnosed with SCLC were enrolled in this study. The association between 103 SNPs in 58 ASCL1 target genes and the response to chemotherapy and survival of patients with SCLC were analyzed.

Results

Among the 103 SNPs, 10 SNPs were significantly associated with th

SUBMITTER: Kim JH 

PROVIDER: S-EPMC6938757 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature