Lipidomic profiling identifies signatures of metabolic risk.

ABSTRACT:

Background

Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors.

Methods

We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors.

Results

Thirty-nine lipids were associated with obesity and eight with dysglycemia in the FHS. Of 32 lipids that

SUBMITTER: Yin X 

PROVIDER: S-EPMC6938899 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature