Age-related retinal thickness in Down's syndrome: A high-risk population for dementia.

ABSTRACT:

Introduction

People with Down's syndrome (DS) have a high prevalence of early-onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treatments. The retina, an extension of the brain, may provide a noninvasive imaging site.

Methods

Forty-nine adults with DS and 36 age-matched controls completed retinal nerve fibre layer (RNFL) assessments using optical coherence tomography. RNFL thickness was analyzed in relation to cognitive status and age and previously acquired cortical thickness and cerebral amyloid β binding data in a subgroup.

Results

RNFL thickness was greater in the DS group and did not show age-related thinning. RNFL correlated positively with cognitive scores

SUBMITTER: Walpert MJ 

PROVIDER: S-EPMC6939044 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature