Unextracted plasma oxytocin levels decrease following in-laboratory social exclusion in young adults with a suicide attempt history.

ABSTRACT: Social exclusion is associated with greater suicide risk and more needs to be known about the biological processes contributing to this association. Oxytocin, a neuropeptide that regulates social interactions, may protect against the negative effects of exclusion by motivating social engagement. Oxytocin levels and desire for social engagement increase when non-psychiatric controls experience acute social exclusion. However, among individuals with borderline personality disorder and chronic depression, oxytocin levels decrease following exclusion. Both of these psychiatric illnesses are associated with high rates of suicidal behavior. No research has examined changes in oxytocin following social exclusion among individuals at risk for suicide. This quasi-experimental study examined differe

SUBMITTER: Chu C 

PROVIDER: S-EPMC6939138 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature