Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children.

ABSTRACT:

Background

Montelukast, a potent oral selective leukotriene-receptor antagonist, inhibits the action of cysteinyl-leukotriene in patients with asthma. Although pharmacokinetic studies of montelukast have been reported in Caucasian adults and children, and showed large inter-individual variability on pharmacokinetics, none of these studies has been explored in Chinese children. Given the potential inter-ethnic difference, the purpose of the present study was to evaluate the effects of developmental factors and pharmacogenetics of CYP2C8 and SLCO2B1 on montelukast clearance in Chinese pediatric patients.

Methods

After the administration of montelukast, blood samples were collected from children and plasma concentrations were determined using an adapted micro high-performance l

SUBMITTER: Li Q 

PROVIDER: S-EPMC6939174 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature