Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.

ABSTRACT:

Objective

potentially inappropriate medications (PIMs) are commonly defined as drugs that should be avoided in older adults because they are considered to have a negative risk-benefit ratio. PIMs are suspected to increase the risk for frailty, but this has yet to be examined.

Design

prospective population-based cohort study.

Setting and participants

a German cohort of community-dwelling older adults (≥60 years) was followed from October 2008 to September 2016.

Methods

in propensity score-adjusted logistic and Cox regression models, associations between baseline PIM use and prevalent/incident frailty were investigated. Frailty was assessed using the definition by Fried and co-workers, PIM were defined with the 2015 BEERS criteria, the BEERS criteria to avoid in

SUBMITTER: Muhlack DC 

PROVIDER: S-EPMC6939286 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature