Impact of mitonuclear interactions on life-history responses to diet.

ABSTRACT: Mitochondria are central to both energy metabolism and biosynthesis. Mitochondrial function could therefore influence resource allocation. Critically, mitochondrial function depends on interactions between proteins encoded by the mitochondrial and nuclear genomes. Severe incompatibilities between these genomes can have pervasive effects on both fitness and longevity. How milder deficits in mitochondrial function affect life-history trade-offs is less well understood. Here, we analyse how mitonuclear interactions affect the trade-off between fecundity and longevity in Drosophila melanogaster. We consider a panel of 10 different mitochondrial DNA haplotypes against two contrasting nuclear backgrounds (w¹¹¹⁸ (WE) and Zim53 (ZIM)) in response to high-protein versus sta

SUBMITTER: Camus MF 

PROVIDER: S-EPMC6939373 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature