Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.

ABSTRACT: Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state is required throughout these phases of activation¹. In CD4 T cells, T-cell-receptor ligation-along with co-stimulatory and cytokine signals-induces a glycolytic anabolic program that is required for biomass generation, rapid proliferation and effector function². CD4 T cell differentiation (proliferation and epigenetic remodelling) and function are orchestrated coordinately by signal transduction and transcriptional remodelling. However, it remains unclear whether these processes are regulated independently of one another by cellular biochemical composition. Here we demonstrate that dis

SUBMITTER: Bailis W 

PROVIDER: S-EPMC6939459 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature