Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function.

ABSTRACT: Down syndrome cell adhesion molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the functional consequences of dscaml1 deficiency in the larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified. Genetic perturbation of dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals. Oculomotor analyses revealed specific deficits related to the dscaml1 mutation, including severe fatigue during gaze stabilization, reduced saccade amplitude and velocity in the light, greater disconjugacy, a

SUBMITTER: Ma M 

PROVIDER: S-EPMC6939486 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature