Circulating MicroRNA-122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD.

ABSTRACT: The impact of circulating microRNA-122 (miR-122) on mortality in patients with histopathologically confirmed nonalcoholic fatty liver disease (NAFLD) remains unclear. We analyzed the overall survival rates in 441 Japanese patients with histopathologically confirmed NAFLD after a median follow-up period of 4.7 years. We also determined the clinicopathologic, genetic, and epigenetic parameters, including serum miR-122 levels, for prediction of mortality. Of the 441 study patients, 21 (4.8%) died during the follow-up period. The cumulative survival rates were 95.4% and 90.6% at the end of 5 and 10 years, respectively. Multivariate analysis identified history of liver cancer (presence; hazard ratio [HR], 4.94; 95% confidence interval [CI], 1.84-13.3), serum miR-122 (<1.00 fold change; HR, 4.35

SUBMITTER: Akuta N 

PROVIDER: S-EPMC6939501 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature