KLF9-dependent ROS regulate melanoma progression in stage-specific manner.

ABSTRACT: Although antioxidants promote melanoma metastasis, the role of reactive oxygen species (ROS) in other stages of melanoma progression is controversial. Moreover, genes regulating ROS have not been functionally characterized throughout the entire tumor progression in mouse models of cancer. To address this question, we crossed mice-bearing knock-out of Klf9, an ubiquitous transcriptional regulator of oxidative stress, with two conditional melanocytic mouse models: Braf^CA mice, where Braf^V600E causes premalignant melanocytic hyperplasia, and Braf^CA/Pten^-/- mice, where Braf^V600E and loss of Pten induce primary melanomas and metastases. Klf9 deficiency inhibited premalignant melanocytic hyperplasia in Braf^CA mice but did not affe

SUBMITTER: Bagati A 

PROVIDER: S-EPMC6939757 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature