The Impact of Gradual and Immediate Nicotine Reduction on Subjective Cigarette Ratings.

ABSTRACT:

Background

A recent clinical trial showed that an immediate transition to very low nicotine content (VLNC) cigarettes, compared with a gradual transition, produced greater reductions in smoking behavior, smoke exposure, and dependence. However, there was less compliance with the instruction to smoke only VLNC cigarettes in the immediate versus gradual reduction condition. The goal of this study was to test whether nicotine reduction method alters subjective ratings of VLNC cigarettes, and whether subjective ratings mediate effects of nicotine reduction method on smoking behavior, smoke exposure, dependence, and compliance.

Methods

This is a secondary analysis of a randomized trial conducted across 10 sites in the United States. Smokers (n = 1250) were randomized to either a

SUBMITTER: Smith TT 

PROVIDER: S-EPMC6939762 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature