Efficacy of Combination Antibiotic Therapy for Refractory Pediatric Inflammatory Bowel Disease.

ABSTRACT:

Background

Recent studies have shown that oral combination antibiotics may improve disease course in refractory inflammatory bowel disease (IBD). Here, we describe the use of combination oral antibiotics as salvage therapy in refractory ulcerative colitis (UC), Crohn's colitis, and IBD-unclassified (IBD-U) at a large pediatric IBD center.

Methods

Clinical response, disease activity indices, adverse events, and clinical outcomes were measured up to 1 year after antibiotic treatment in this retrospective cohort study of children with medically refractory IBD colitis.

Results

Sixty-three patients with refractory UC, Crohn's colitis, and IBD-U (median age [interquartile range {IQR}], 15.3 [11.2-16.5] years; median disease duration [IQR], 1.2 [0.41-4.6] years) received a c

SUBMITTER: Breton J 

PROVIDER: S-EPMC6939824 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature