Roles of OGG1 in transcriptional regulation and maintenance of metabolic homeostasis.

ABSTRACT: Cellular damage produced by conditions generating oxidative stress have far-reaching implications in human disease that encompass, but are not restricted to aging, cardiovascular disease, type 2 diabetes, airway inflammation/asthma, cancer, and metabolic syndrome including visceral obesity, insulin resistance, fatty liver disease, and dyslipidemia. Although there are numerous sources and cellular targets of oxidative stress, this review will highlight literature that has investigated downstream consequences of oxidatively-induced DNA damage in both nuclear and mitochondrial genomes. The presence of such damage can in turn, directly and indirectly modulate cellular transcriptional and repair responses to such stressors. As such, the persistence of base damage can serve as a key regulator in

SUBMITTER: Sampath H 

PROVIDER: S-EPMC6939861 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature