Gold Nanoparticle Transforms Activated Cancer-Associated Fibroblasts to Quiescence.

ABSTRACT: Activated cancer-associated fibroblasts (CAFs) play a major role in the poor outcome in many diseases including pancreatic cancer. Normally quiescent with high lipid content and low proliferative capacity, CAFs receiving cues from cancer cells in the tumor microenvironment become activated and transformed into a lipid-deprived and highly proliferative myofibroblast type phenotype. Therefore, reversal of activated fibroblasts to the quiescence state is an important area of investigation that may help the therapeutic management of a number of diseases including pancreatic cancer. Here, we describe a unique biological function of gold nanoparticles (GNPs) and demonstrate that GNPs may be used to transform activated CAFs to quiescence and provide insights into the underlying molecular mechanis

SUBMITTER: Hossen MN 

PROVIDER: S-EPMC6939884 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature