Genetic variation in thyroid folliculogenesis influences susceptibility to hypothyroidism-induced hearing impairment.

ABSTRACT: Maternal and fetal sources of thyroid hormone are important for the development of many organ systems. Thyroid hormone deficiency causes variable intellectual disability and hearing impairment in mouse and man, but the basis for this variation is not clear. To explore this variation, we studied two thyroid hormone-deficient mouse mutants with mutations in pituitary-specific transcription factors, POU1F1 and PROP1, that render them unable to produce thyroid stimulating hormone. DW/J-Pou1f1^dw/dw mice have profound deafness and both neurosensory and conductive hearing impairment, while DF/B-Prop1^df/df mice have modest elevations in hearing thresholds consistent with developmental delay, eventually achieving normal hearing ability. The thyroid glands of Pou1f1 mutants are

SUBMITTER: Mortensen AH 

PROVIDER: S-EPMC6939890 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature