Apolipoprotein E and gray matter volume loss in patients with mild cognitive impairment and Alzheimer disease.

ABSTRACT:

Purpose

To examine the influence of apoliprotein E ε4 allele (APOE4) carrier status on disease progression by evaluating the rate of regional gray matter (GM) volume loss and disease severity in patients with newly diagnosed Alzheimer disease (AD) and stable amnestic mild cognitive impairment (MCI).

Materials and methods

This study was approved by the institutional review board and was HIPAA compliant. All subjects or their legal representatives gave informed consent for participation. Ninety-five subjects (63 male; average age, 77.1 years; age range, 58-91 years; 51 APOE4 carriers; 44 noncarriers) with either documented MCI to AD conversion or stable amnestic MCI underwent three yearly magnetic resonance imaging examinations. Voxel-based morphometry for image postprocessing

SUBMITTER: Spampinato MV 

PROVIDER: S-EPMC6939949 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature