Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring attention-deficit hyperactivity disorder and autistic traits.

ABSTRACT:

Background

Prenatal exposure to organophosphate (OP) pesticides has been associated with altered neuronal cell development and behavioral changes in animal offspring. However, the few studies investigating the association between prenatal OP pesticide exposure and neurodevelopmental outcomes such as Attention-Deficit Hyperactivity Disorder (ADHD) and autistic traits in children produced mixed findings.

Objective

The objective of the present study was to examine whether maternal urinary concentrations of OP pesticide metabolites are associated with ADHD and autistic traits in children participating in the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands.

Method

Maternal concentrations of 6 dialkylphosphates (DAPs) were measured using

SUBMITTER: van den Dries MA 

PROVIDER: S-EPMC6939991 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature