Involvement of hydrogen sulfide in the progression of renal fibrosis.

ABSTRACT:

Objective

Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling molecule exerting a wide range of biologic actions in our body. This review illustrates recent experimental findings on the mechanisms underlying the therapeutic effects of H2S against renal fibrosis and highlights its potential in future clinical application.

Data sources

Literature was collected from PubMed until February 2019, using the search terms including "Hydrogen sulfide," "Chronic kidney disease," "Renal interstitial fibrosis," "Kidney disease," "Infl

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6940064 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature