Post-acute white matter microstructure predicts post-acute and chronic post-concussive symptom severity following mild traumatic brain injury in children.

ABSTRACT:

Introduction

Mild traumatic brain injury (TBI) is a global public health concern that affects millions of children annually. Mild TBI tends to result in subtle and diffuse alterations in brain tissue, which challenges accurate clinical detection and prognostication. Diffusion tensor imaging (DTI) holds promise as a diagnostic and prognostic tool, but little research has examined DTI in post-acute mild TBI. The current study compared post-acute white matter microstructure in children with mild TBI versus those with mild orthopedic injury (OI), and examined whether post-acute DTI metrics can predict post-acute and chronic post-concussive symptoms (PCS).

Materials and methods

Children aged 8-16.99 years with mild TBI (n = 132) or OI (n = 69) were recruited at emergency departme

SUBMITTER: Ware AL 

PROVIDER: S-EPMC6940617 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature