Is There an Independent Role of TERT and NF1 in High Grade Gliomas?

ABSTRACT:

Background

High grade glioma molecular profiling is of particular interest in neurooncology. The role of telomerase reverse transcriptase (TERT) varies dependent upon other molecular parameters. We explored the role of TERT in 101 high-grade gliomas.

Methods

A total of 101 patients (pts) with grade III-IV gliomas treated with standard of care and informative tumor genotypes were included in the present study. Of 55 genes targeted with the next-generation sequencing panel, mutations (muts) were found in 37; these were included in the analysis. TERT mut were tested with Sanger sequencing. MGMT promoter methylation status was determined by methylation specific PCR.

Results

270 mut were detected in 92/101 tumors (91.1%). TERT was the most frequently mutated gene (74.3%).

SUBMITTER: Razis E 

PROVIDER: S-EPMC6940679 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature