Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals.

ABSTRACT:

Background

Pulmonary dysfunction is associated with elevated risk of cognitive decline. However, the mechanism underlying this relationship has not been fully investigated. In this study, we investigate the relationships between pulmonary function, cerebral small vessel disease (CSVD) markers, cortical thickness, and the Mini-Mental Status Examination (MMSE) scores in cognitively normal individuals.

Methods

We used a cross-sectional study design. We identified 1924 patients who underwent pulmonary function testing, three-dimensional brain magnetic resonance imaging (MRI), and the MMSE. Pulmonary function was analyzed according to the quintiles of percentage predicted values (% pred) for forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV₁). Regardi

SUBMITTER: Kim Y 

PROVIDER: S-EPMC6940695 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature