Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4.

ABSTRACT: The four member family of "Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators", CNNMs, are the least-studied mammalian magnesium transport mediators. CNNM4 is abundant in the brain and the intestinal tract, and its abnormal activity causes Jalili Syndrome. Recent findings show that suppression of CNNM4 in mice promotes malignant progression of intestinal polyps and is linked to infertility. The association of CNNM4 with phosphatases of the regenerating liver, PRLs, abrogates its Mg²⁺-efflux capacity, thus resulting in an increased intracellular Mg²⁺ concentration that favors tumor growth. Here we present the crystal structures of the two independent intracellular domains of human CNNM4, i.e., the Bateman module and the cyclic nu

SUBMITTER: Gimenez-Mascarell P 

PROVIDER: S-EPMC6940986 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature