The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli.

ABSTRACT: BACKGROUND:Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections, including neonatal meningitis, septicemia, and urinary tract (UT) infections (UTIs). Antibiotic therapy has been the conventional treatment for such infections, but its efficacy has decreased due to the emergence of antibiotic-resistant bacteria. Identification and characterization of bacterial factors that contribute to the severity of infection would facilitate the development of novel therapeutic strategies. The ExPEC periplasmic protease Prc contributes to the pathogen's ability to evade complement-mediated killing in the serum. Here, we further investigated the role of the Prc protease in ExPEC-induced UTIs and the underlying mechanism. MET

SUBMITTER: Huang WC 

PROVIDER: S-EPMC6941253 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature