Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas.

ABSTRACT:

Background

Gliomas account for the major part of primary brain tumors. Based on their histology and molecular alternations, adult gliomas have been classified into four grades, each with distinct biology and outcome. Previous studies have focused on cell-line-based models and patient-derived xenografts (PDXs) from patient-derived glioma cultures for grade IV glioblastoma. However, the PDX of lower grade diffuse gliomas, particularly those harboring the endogenous IDH mutation, are scarce due to the difficulty growing glioma cells in vitro and in vivo. The purpose of this study was to develop a panel of patient-derived subcutaneous xenografts of different grade gliomas that represented the heterogeneous histopathologic and genetic features of human gliomas.

Methods

Tumor piec

SUBMITTER: Zeng W 

PROVIDER: S-EPMC6941273 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature