Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling.

ABSTRACT: BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs commonly enable subsets of cancer cells to survive therapy. In addition to local recurrence, these cells escape a primary tumor and migrate through the stroma to access the circulation and metastasize to different organs, leading to an incurable disease. As such, therapeutics that block migration and invasion of cancer cells may inhibit or reduce metastasis and significantly improve cancer therapy. This is particularly more important for cancers, such as triple negative breast

SUBMITTER: Shahi Thakuri P 

PROVIDER: S-EPMC6941316 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature